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Below, we look in more detail at the three most important types of RNA. The nitrogen bases in DNA are the basic units of genetic code, and their correct ordering and pairing is essential to biological function. The four bases that make up this code are adenine A , thymine T , guanine G and cytosine C. Bases pair off together in a double helix structure, these pairs being A and T, and C and G. RNA molecules, by comparison, are much shorter 3. Eukaryotic cells, including all animal and plant cells, house the great majority of their DNA in the nucleus, where it exists in a tightly compressed form, called a chromosome 4.

This squeezed format means the DNA can be easily stored and transferred. In addition to nuclear DNA, some DNA is present in energy-producing mitochondria, small organelles found free-floating in the cytoplasm, the area of the cell outside the nucleus.

The three types of RNA are found in different locations. If it receives the correct signal from the ribosome, it will then hunt down amino acid subunits in the cytoplasm and bring them to the ribosome to be built into proteins 5. Ribosomes are formed in an area of the nucleus called the nucleolus, before being exported to the cytoplasm, where some ribosomes float freely.

Other cytoplasmic ribosomes are bound to the endoplasmic reticulum, a membranous structure that helps process proteins and export them from the cell 5. Meet The Author. Ruairi J Mackenzie. RNA Functions. Citation: Clancy, S. Nature Education 7 1 The more researchers examine RNA, the more surprises they continue to uncover. What have we learned about RNA structure and function so far? Aa Aa Aa. Figure 1. Figure Detail. Figure 2. Figure 3. Figure 4. Ribosomal RNA rRNA , which forms the structural and functional components of the ribosome, is present in bacterial and eukaryotic cells.

In eukaryotic cells, it is present in the cytoplasm. In eukaryotes, it's found in the nucleus and cytoplasm. Transfer RNA tRNA , which helps incorporate amino acids into growing polypeptide chains, is present in bacterial and eukaryotic cells.

In eukaryotes, it's found in the cytoplasm. Figure 8. Figure 9. More and More RNAs. For instance, short RNAs are not only part of organelles like ribosomes and spliceosomes, but also of some enzymes. For example, the enzyme telomerase , which adds nucleotides to the ends of chromosomes, is composed of a nucleotide RNA and several proteins.

Juli Feigon at the University of California, Los Angeles, together with postdoctoral scholar Carla Theimer and graduate student Craig Blois, first solved the structure of an essential piece of this RNA by nuclear magnetic resonance spectroscopy Theimer et al.

References and Recommended Reading Berget, S. Cell 20 , — Evans, R. Cell 12, — Holley, R. New York, Freeman, Rich, A. Cell , — Theimer, C. Article History Close. Share Cancel. Revoke Cancel. Keywords Keywords for this Article. Save Cancel. Flag Inappropriate The Content is: Objectionable. Flag Content Cancel. Email your Friend.

Submit Cancel. This content is currently under construction. Explore This Subject. Applications in Biotechnology. DNA Replication. Jumping Genes. Discovery of Genetic Material. Gene Copies. No topic rooms are there. Or Browse Visually. Other Topic Rooms Genetics. Student Voices. Creature Cast. Simply Science. Figure 1.

Figure 2. Cells access the information stored in DNA by creating RNA to direct the synthesis of proteins through the process of translation. Proteins within a cell have many functions, including building cellular structures and serving as enzyme catalysts for cellular chemical reactions that give cells their specific characteristics. If DNA serves as the complete library of cellular information, mRNA serves as a photocopy of specific information needed at a particular point in time that serves as the instructions to make a protein.

The mRNA then interacts with ribosomes and other cellular machinery Figure 3 to direct the synthesis of the protein it encodes during the process of translation see Protein Synthesis. Figure 3. In eukaryotes, synthesis, cutting, and assembly of rRNA into ribosomes takes place in the nucleolus region of the nucleus, but these activities occur in the cytoplasm of prokaryotes. Neither of these types of RNA carries instructions to direct the synthesis of a polypeptide, but they play other important roles in protein synthesis.

Ribosomes are composed of rRNA and protein. The rRNA ensures the proper alignment of the mRNA, tRNA, and the ribosomes; the rRNA of the ribosome also has an enzymatic activity peptidyl transferase and catalyzes the formation of the peptide bonds between two aligned amino acids during protein synthesis. Although rRNA had long been thought to serve primarily a structural role, its catalytic role within the ribosome was proven in Because of the importance of this work, Steitz shared the Nobel Prize in Chemistry with other scientists who made significant contributions to the understanding of ribosome structure.

It carries the correct amino acid to the site of protein synthesis in the ribosome. It is the base pairing between the tRNA and mRNA that allows for the correct amino acid to be inserted in the polypeptide chain being synthesized Figure 4.

Any mutations in the tRNA or rRNA can result in global problems for the cell because both are necessary for proper protein synthesis Table 1.

Figure 4. A tRNA molecule is a single-stranded molecule that exhibits significant intracellular base pairing, giving it its characteristic three-dimensional shape. Thus, RNA clearly does have the additional capacity to serve as genetic information.



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