What is the difference between hctz and chlorthalidone

However, HCTZ seems to be the more commonly used diuretic. At the same time, the two medications do not show significant differences in their safety profile although data concerning their effect on serum potassium and sodium is scarce. Additional studies investigating rates of hypokalemia and hyponatremia should be performed. Thiazide-type diuretics are one of the initial agents, which are used in cases of uncomplicated hypertension. Hypertension: steps forward and steps backward: the Joint National Committee fifth report.

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Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil. Am J Med. A randomized, comparative study evaluating the efficacy and tolerability of losartan-low dose chlorthalidone 6.

Efficacy of low-dose chlorthalidone and hydrochlorothiazide as assessed by h ambulatory blood pressure monitoring. J Am Coll Cardiol. Risk of hyponatremia with diuretics: chlorthalidone versus hydrochlorothiazide. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. J Am Med Assoc. National Heart, Lung and Blood Institute; The complete database of evidence-based questions and answers is copyrighted by FPIN.

This series is coordinated by John E. Delzell, Jr. Want to use this article elsewhere? Get Permissions. Read the Issue. Sign Up Now. Previous: Evaluation of Patients with Leukocytosis. Next: Petechiae in a Newborn. Hydrochlorothiazide for Treatment of Hypertension. Dec 1, Issue. Clinical Question Is chlorthalidone more effective than hydrochlorothiazide for treatment of hypertension? Baseline characteristics for Optum with stratification eTable 5.

Baseline characteristics for PanTher with stratification eTable 6. Baseline characteristics for Optum with matching eTable 8.

Baseline characteristics for PanTher with matching eTable 9. Effectiveness and safety for meta-analysis for stratified on-treatment these are the primary results reported in the main paper eTable Effectiveness and safety for meta-analysis for stratified intent-to-treat eTable Effectiveness and safety for meta-analysis for matching on-treatment eTable Effectiveness and safety for meta-analysis for matching intent-to-treat eReferences.

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Comparative antihypertensive effects of hydrochlorothiazide and chlorthalidone on ambulatory and office blood pressure. Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil. Am J Med.

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Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate. Meta-analysis of dose-response characteristics of hydrochlorothiazide and chlorthalidone: effects on systolic blood pressure and potassium.

Am J Hypertens. Long-term effects of chlorthalidone versus hydrochlorothiazide on electrocardiographic left ventricular hypertrophy in the multiple risk factor intervention trial.

Andrew E. Schuemie, PhD. This Medical News article discusses a head-to-head comparison of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for high blood pressure treatment.

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Thank You. Thiazide diuretics are a mainstay for the treatment of hypertension. Although there are several thiazide diuretics currently available, hydrochlorothiazide HCTZ continues to be the most popular thiazide used for treating high blood pressure. This is despite several clinical trials that have used and documented the benefits of chlorthalidone for hypertension management.